Mission Statement

Tau's Normal Functions

Modeling Tau Polymerization

• In Vitro paradigm
• Isoform differences
• Point mutations
• Post-translational modifications
• Oxidative conditions
• Role of the amino terminus
• Role of the carboxy terminus
• Model for Tau Polymerization
• Tau, Caspase Cleavage, and Apoptosis

Tau-related neurodegenerative diseases

• Alzheimer's Disease
• Progressive Supranuclear Palsy
• Corticobasal Degeneration
• Pick's Disease

• Cellular tau pathology (light microscopy)
• Neuronal Pathology
• Neurofibrillary tangles, Neuropil threads, and Neuritic plaques
• Globose tangles
• Pick bodies
• Glial Pathology
• Thorny astrocytes
• Tufted astrocytes
• Astrocytic plaques
• Coiled bodies
• Glial Threads
• Microglia
Cellular tau pathology (laser confocal microscopy)

References

Lab Publications

Lab members

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