Pick's Disease Pathology
(PiD) is one of the frontal lobar dementias, primarily
characterized by the presence of distinct argyrophilic (silver staining)
spherical inclusions called Pick bodies and globose neurons.
The Pick body is composed of numerous tau fibrils arranged
in a disorderly array (Marayama,
et. al., 1990; Takauchi,
et. al., 1984). Tau protein is a major component of the Pick
body, but numerous other antibodies also stain Pick bodies, including those
to ubiquitin, alpha-synuclein, and apolipoprotein E.
While Pick bodies are primarily found in neurons, small,
Pick-body like inclusions have been described in glial cells (Komori,
Page written by Michelle E. King
Photos by Michelle E. King